Functional human liver cells grown in the lab

In new research appearing in the journal Nature Biotechnology, an international research team led by The Hebrew University of Jerusalem describes a new technique for growing human hepatocytes in the laboratory. This groundbreaking development could help advance a variety of liver-related research and applications, from studying drug toxicity to creating bio-artificial liver support for patients awaiting transplantations.

The liver is the largest internal organ in the human body, serving as the main site of metabolism. Human hepatocytes -- cells that comprise 85% of the liver -- are routinely used by the pharmaceutical industry for study of hepatotoxicity, drug clearance and drug-drug interactions. They also have clinical applications in cell therapy to correct genetic defects, reverse cirrhosis, or support patients with a liver-assist device.

Regrettably, while the human liver can rapidly regenerate in vivo, recognized by the ancient Greeks in the myth of Prometheus, this capability to proliferate is rapidly lost when human cells are removed from the body. Thus far, attempts to expand human hepatocytes in the laboratory resulted in immortalized cancer cells with little metabolic function. The scarce supply of human hepatocytes and this inability to expand them without losing function is a major bottleneck for scientific, clinical and pharmaceutical development.

To address this problem, Prof. Yaakov Nahmias, director of the Alexander Grass Center for Bioengineering at the Hebrew University of Jerusalem, partnered with leading German scientists at upcyte technologies GmbH (formerly Medicyte) to develop a new approach to rapidly expand the number of human liver cells in the laboratory without losing their unique metabolic function.

Based on early work emerging from the German Cancer Research Center (DKFZ) on the Human Papilloma Virus (HPV), the research team demonstrated that weak expression of HPV E6 and E7 proteins released hepatocytes from cell-cycle arrest and allowed them to proliferate in response to Oncostatin M (OSM), a member of the interleukin 6 (IL-6) superfamily that is involved in liver regeneration. Whereas previous studies caused hepatocytes to proliferate without control, turning hepatocytes into tumor cells with little metabolic function, the researchers carefully selected colonies of human hepatocytes that only proliferate in response to OSM. Stimulation with OSM caused cell proliferation, with doubling time of 33 to 49 hours. Removal of OSM caused growth arrest and hepatic differentiation within 4 days, generating highly functional cells. The method, described as the upcyte© process (upcyte technologies GmbH), allows expanding human hepatocytes for 35 population doubling, resulting in 1015 cells (quadrillion) from each liver isolation. By comparison, only 109 cells (billion) can be isolated from a healthy organ.

"The approach is revolutionary," said Dr. Joris Braspenning, who led the German group. "Its strength lies in our ability to generate liver cells from multiple donors, enabling the study of patient-to-patient variability and idiosyncratic toxicity." The team generated hepatocyte lines from ethnically diverse backgrounds that could be serially passaged, while maintaining CYP450 activity, epithelial polarization, and protein expression at the same level as primary human hepatocytes. Importantly, the proliferating hepatocytes showed identical toxicology response to primary human hepatocytes across 23 different drugs.

"This is the holy grail of liver research," said Prof. Nahmias, the study's lead author. "Our technology will enable thousands of laboratories to study fatty liver disease, viral hepatitis, drug toxicity and liver cancer at a fraction of the current cost." Nahmias noted that genetic modifications preclude using the cells for transplantation, "but we may have found the perfect cell source for the bio-artificial liver project."

Credit to sciencedaily.com

http://www.sciencedaily.com/releases/2015/11/151126104303.htm

RUSSIA “FULLY MOBILIZED,” STRIKES TURKISH TARGETS IN SYRIA

“The president is mobilized, fully mobilized, mobilized to the extent that circumstances demand,” Vladimir Putin’s spokesman, Dmitry Peskov, said on  Saturday.

“The circumstances are unprecedented. The gauntlet thrown down to Russia is unprecedented. So naturally the reaction is in line with this threat,” he told Russia’s “News on Saturday” TV program.

In addition to placing S-400 missiles in Syria on Thursday and deploying the Moskva missile cruiser, Russia is preparing to wage electronic warfare.

According to Lieutenant-General Evgeny Buzhinsky Russia will begin using land and air-based jamming systems to protect its aircraft.

“Regarding the possible impact of this incident on the further developments of the operation in Syria, I think that from now on, our pilots will be more attentive and if the Turks continue behaving in such a manner, Russia will have to resort to electronic jamming and other warfare equipment, including special aircraft with special equipment on board, in order to protect our pilots from being stricken with missiles,” Buzhinsky told Sputnik, the Russian news service.

Russia has reportedly struck more than 450 targets in Syria since its Su-24 warplane was shot down on the Syria-Turkey border. The strikes are concentrated primarily in the Latakia and Idlib provinces.

On Thursday Russia bombed the Bab al-Hawa border crossing used by the Turkish government to transfer weapons and money to the jihadists. According to the Israeli source DEBKAfile, targets on the Syrian side of the border post included trailers belonging to the Turkish Humanitarian Relief Foundation, an organization accused of ties to al-Qaeda.

“DEBKAfile’s military and intelligence sources report that since Wednesday night, Nov. 25, Russian heavy bombers and warplanes have been hitting every Turkish vehicle moving or stationary inside Syria,” the website reported on Friday.

Turkey has suspended military flights over Syria and the United States halted airstrikes after Russia deployed its S-400 anti-aircraft system at the Khmeimim airbase.

On Friday a spokesperson for the Combined Joint Task Force Operation Inherent Resolve said the halt “has nothing to do with the S400 deployment” in Syria.

“The fluctuation or absence of strikes in Syria reflects the ebb and flow of battle,” the spokesperson said.

Credit to Infowars

Large Shipment of 847 Shotguns Seized In Italy

BREAKING: NORTH KOREA THREATENS TO NUKE TURKEY

ALERT about WWIII

Putin Orders Complete Destruction Of Turkish President, Family And Government

The Ministry of Defense (MoD) is reporting today that President Putin has authorized an unprecedented “asymmetric warfare” action, to include “war by proxy”, to destroy the family and government of Turkish President Recep Erdogan in retaliation for the deliberate downing of an Aerospace Forces Sukhoi Su-24M bomber aircraft on 24 November over Syria in a bid to prevent a larger war with the nation of Turkey as a whole.

According to this MoD report, and as we had previously reported on, the deliberate ambushing and shoot down of this Su-24M was “directed/organized” by rogue elements operating within the Turkish government and United States Central Intelligence Agency (CIA) who were “partners/collaborators” in an oil-for-weapons scheme involving Islamic State terrorists operating in Syria run by Turkey’s President Erdogan’s son Bilal Erdogan.

Bilal Erdogan, this report continues, is the silent mastermind who has been responsible for converting millions of barrels of Syrian oil controlled by Islamic State terrorists into hundreds of millions of dollars of revenue in a scheme so vast that President Putin described it as a “living oil pipeline” comprised of “vehicles, carrying oil, lined up in a chain going beyond the horizon”.

With the money earned from this sale of the Islamic States oil, this report notes, American weapons and ammunition were then bought from the CIA and transported back into Syria by Turkey’s National Intelligence Organization (MİT) to Islamic State terrorists—which was documented and verified by the editor-in-chief of the Turkish Cumhuriyet newspaper who upon the release of this information was ordered arrested yesterday by President Erdogan on treason and espionage charges.

With Aerospace Forces having destroyed over 1,000 fuel tankers in the week prior to 24 November carrying illegal Islamic State oil into Turkey, MoD analysts in this report state, Bilal Erdogan, along with his MIT and CIA “accomplices” then ordered the “shootdown by ambush” of Russia’s Su24-M bomber aircraft with Turkish Prime Minister, and Erdogan family ally, Ahmet Davutoglu admitting that he personally gave the order to fire on the aircraft—and which was filmed by Islamic State terrorists who knew where and when to “get that exclusive footage”, as reported by Federation Colonel-General Viktor Bondarev.

To the Western propaganda effort to “disguise/distort” this war crime against the Federation by Turkey, this report says, it has fallen into to many absurdities to count—including the impossibility of this Su24-M being able to fly over Turkish territory at a speed at which if true it had would have fallen from the sky, and which Wikileaks stated about: “Journalists: Learn to do basic maths. Look at Turkey’s statement to UN: 1.15 miles / 17 seconds x 60 x 60 = 243 miles/hour = 391 km/hour”.

Even worse about the Western propaganda, this report notes, is an obvious Erdogan-MIT-CIA fabricated recording of the alleged warning given to the Su24-M bomber aircraft—but which Turkish authorities have informed the Russian military attache that they did not provide the media with any audio recordings of alleged radio contacts between their F-16 fighter and the downed Russian Su-24M bomber aircraft because they don’t exist.

To President Putin’s war order against the Erdogan family and regime, this report continues, it has included the obliteration of the Islamic State forces in the area where this plane was downed and now allows Aerospace Forces to shoot down all enemy planes and objects which pose, or can pose, a threat to the serviceman of Russia in Syria.

And as stated by President Putin to the media this morning, these measures let everyone know clearly that the next time any foreign plane tries to carry out aggression against the Russian Air Force, air base, or the military personnel of Russia in Syria—they will be, without any doubts, immediately destroyed—and the Triumph S-400 air defense missile complex wasn’t just deployed to Syria for appearances.

With Turkey now massing tanks on their border with Syria, this report continues, President Putin’s war plan against the Erdogan regime also includes the destruction of the Turkish economy and the 1 January 2016 planned suspension of visa-free travel between Russia and Turkey—and, perhaps most dangerously, the immediate deployment to the Kurdish Syrian independent region of Rojava a contingent of Spetsnaz (Special Forces) troops to aid these people in their fight against the Islamic State.

With Turkey having bombed Kurdish fighters in Iraq and Syria 300 times and Islamic State targets only three, this report notes, the Erdogan regimes greatest fears have been revealed as being against these mainly women and girl Kurdish fighters in Rojavadecimating Islamic State terrorists—and who by their success has invigorated the freedom thoughts of Turkey’s own Kurdish minority President Erdogan has vowed to destroy.

To if the United States would go to war against Russia to protect the Islamic State on the side of Turkey, this report concludes, it appears unlikely after the Obama regime removed all of their military forces Patriot Missiles from Turkish territory leaving that nation defenseless against Federation retaliation if needed.

And even though not contained in this MoD report, it is worth noting that should the Obama regime engage in war with Russia over the Islamic State, the American fighters entering the battlefield have now become so weak that this past week, the elite US military academy for training officers, West Point, was forced to ban pillow fights and the students at the University of Massachusetts were provided emergency grief counseling after they inadvertently saw a Confederate Battle Flag sticker on someone’s computer.

Credit to eutimes.ne

http://www.eutimes.net/2015/11/putin-orders-complete-destruction-of-turkish-president-family-and-government/

Former CIA Operative Reveals That ET Walks Among Us

The current pope is no stranger to the topic of ET’s.

Recently, I wrote an article in which I exposed a TV show, TNT’s Legends, which depicted a radical Muslim terrorist attack upon Paris. The show was representative of what we call “predictive programming. Predictive programming occurs when Hollywood reveals a major event (e.g. the Simpsons predicting 9/11), or a major shift in an attitude or philsophy (e.g. Man of Steel and the subject of transhumanism).

I have long admitted the existence of predictive programming. However, there was one area in which I have always maintained a blind spot, in this arena, and that would be in the area of extraterrestrial life and its relationship with the present inhabitants on the earth. My skepticism was no doubt fueled by my fathers position on the topic as he worked with former Nazi scientists in reverse engineering drawing board technology to the laboratory. He said that the Nazis to a person claimed their advanced technology and ideas came from extraterrestrial beings. My father felt it was likely that the Germans were parroting a cover story that was created for them by their handlers. However, my father did not likely have access to the same quality sources that I had following his death in 1985.

Vance Davis and Bill Pawelec

Art Bell, the all-time King of night time radio sitting in the Captain’s chair.

One night in 1993, as fate would have it, I was listening, for the very first time, to Coast to Coast with Art Bell, and Art was interviewing Vance Davis. During the interview, Vance, a former NSA operative attached to NATO, revealed he that he became aware that both NATO and the NSA were fully aware of the presence, on the Earth, of representatives of several  extraterrestrial civilizations who had their own individual designs upon the planet. During the interview, Vance’s description of advanced technology was eerily familiar and completely matched what my father had revealed to me eight years prior when he was dying from a rare lung disease.

Following the interview, I attempted to reach out to Vance and instead Bill Pawelec, who had done much contract work for the CIA reached out to me. Bill’s reason for contacting me  was to ascertain my credibility which was easy to do because Bill had contact with my father while both of them were working at Sunstrand Electronics in Westminster, Colorado. It was at Sunstrand that my father and Bill were working on earth-penetrating tomography in which activity of one to two miles deep beneath the earth could be observed by satellite. In the process of our early communications, I became good friends with Bill. Eventually, I was introduced to Vance Davis and he and I also became very close and I was exposed to a portion of Earth history that few have ever heard about (e.g. past civilizations and advanced weapons systems, etc).

New Energy Source

Ken Lay CEO of ENRON

Vance Davis

By 1997, Vance and Bill had developed a protoype energy source which would have revolutionized energy usuage and distribution on the planet. Along with former Apollo astronaut, Ken Arnold, whose home I had visited in 1997 with Bill Pawelec and Vance Davis, they set out to revolutionize the energy paradigm on this planet. Subsequently, I learned that this technology was eventually brought to the attention of ENRON and were covertly working on integration of what Vance had learned while in the NSA and what Bill learned as a contract agent for the CIA. You remember ENRON don’t you? It was one of the premiere energy companies in the world that was known for their stunning innovations.

Eventually, Ken Lay, the embattled CEO of ENRON was framed for insider trading, embezzlement  and a host of other charges. ENRON was significantly dismantled, brick by brick. Lay (2006) allegedly took the path of suicide, err… a heart attack, as an escape from facing his legal consequences. However, even CNNMoney.com sarcastically speculated that Lay never died. Speculation abounded that his suicide was faked and he was allowed to enter Federal Witness Protection. Now why would the Feds allow Lay to escape justice, or was he just framed? In short, and according to both Pawelec and Davis, Lay’s intentions to unleash power sources upon the world without the approval of the global elite, was met with a swift response. Lay was framed and with these events, the hopes of a new energy source that would supplant oil as the primary energy source on the planet was gone. But apparently Lay had leverage and was allowed to go into hiding.

During the time that Davis and Pawelec were working in conjunction with ENRON, they never fully confided in me the extent and full nature of what they were jointly working on. It was only following the collapse of ENRON was I told any of the details.

Vance Davis eventually faded into the background and I have only had very limited contact with him. I do not know if he was threatened into silence and then he went conspicuously dark. He appeared on my show several years ago and spoke of some of these events in a superficial manner. Two years ago, I received an email from Vance where he told how he was doing as he had moved his family to Kansas. Otherwise, he simply dropped out of site. I have long thought he was protected because at one point he had escaped execution, by Presidential pardon (George H. W. Bush). Davis and five other deserted their posts in Germany, in the Gulf Breeze Six incident, when they learned of the ET and related theats to the planet. I believe that Vance had a measure of protection because the secret reasons behind his Presidential pardon.

Bill Pawelec, had no such protection as he tried to keep his ideas alive and wanted to form a “protected community” of sorts in the San Luis Valley in Colorado, based upon this unique technology. To explore this possibility, Bill moved to Pagosa Springs, CO. with the new love of his life, Annie DeRiso. Annie and I became close friends following Bill’s

Annie DeRiso, the retired News Director of The Common Sense Show

death from a form of quick acting cancer. And eventually, Annie became the News Director for The Common Sense Show, a position she held for six years. It was there that Bill contracted quick acting cancer and died in 2007.

Pawelec knew what he was working on had inherent risks to his safety. In 2001, I advised him to record and distribute for safekeeping some kind of leverage of what he knew, so he would not become a victim. My own father employed a similar strategy when left covert projects in the late 197o’s as too many of his colleagues were meeting an untimely end.

In 2001, Bill Pawelec allowed himself to be interviewed by Dr. Steven Greer, who was heading an ET disclosure project led by Generals, Colonel’s and government scientists. Bill was interviewed by Dr. Greer just prior to the unveling of the Disclosure Project. Greer agreed to keep the interview off the books until after Bill’s death. Immediately following Bill’s death, in 2007, Greer aired the interview about Bill’s knowledge on the ET technology question. At the very end of the interview, Bill made it clear he was holding back additional information. The information that he held back was the ET had infiltrated many government bureaucracies and was walking among us guiding the direction of the planet. These were Bill’s words, not mine.

As I look back upon this time, I believe that Bill’s interview with Dr. Greer kept him from becoming an immediate violent death statistic. However, his eventual death from quick acting cancer would not be as suspicious. Both Annie and I felt that Bill was taken out for what he knew.

Annie and Bill Pawelec

Disclosures From Bill Pawelec

Several years ago, I was interviewing Jim Marrs about the existence and nature of secret societies. Out of the blue, Jim said that “You really cannot understand the nature of secret societies without looking at the ET issue”. I have come to understand what Jim meant by that comment.

Bill Pawelec’s revelations regarding disclosure of the alien issue to Dr. Greer was revealing, but very incomplete.

Click to watch William (Bill) Pawlec Interview.

(ttp://www.thecommonsenseshow.com/about/)

What Bill did not tell Dr. Greer that he clearly told me was that ET’s are not only interacting with the elite, many have operatives who are living and walking among us.

Conclusion

I was publicly quiet about this issue for many years, for many reasons, most of which centered around the topic of credibility.

I have decided it is time to talk and to reveal what I have been told.

Imminent disclosure is at hand. Hollywood is deeply involved in predictive programming in a PSYOPS to prepare the people about what is really going on with regard to the earth and its “guided” future.

In Part Two, I will be revealing how a compelling case for predictive programming in relation to the ET issue can be made. The pattern is undeniable and it will be covered in tomorrow’s article. The end result implications are the most profound news event on the planet.

Credit to Common Sense